// multi-utility computation suite · offline · instant · precise
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health.henderson-hasselbalch-bioavail Calculator
Applies the Henderson-Hasselbalch equation to calculate the ionised and unionised fractions of a weak acid or base drug at physiological pH. Only the unionised fraction crosses lipid membranes — this determines GI absorption, CNS penetration, and tubular reabsorption.
Inputs
Drug Pka
Reference formula or conversion factor shown for context.
Compartment Ph
Reference formula or conversion factor shown for context.
Drug Type
Reference formula or conversion factor shown for context.
Results
un-ionized fraction
Sample size or count used in the calculation.
ionized fraction
Sample size or count used in the calculation.
un-ionized:ionized ratio
The proportional relationship between two quantities.
Henderson-Hasselbalch
Sample size or count used in the calculation.
membrane permeability
Sample size or count used in the calculation.
aspirin in stomach (pH 1.5)
pH of the solution. Below 7: acidic. 7: neutral. Above 7: basic (alkaline).