// multi-utility computation suite · offline · instant · precise
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│ computation suite │
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sci.drug-bioavailability-Foral Calculator
Calculates oral bioavailability F = AUC_oral/AUC_IV from area under the plasma concentration-time curve for oral vs intravenous dosing. High first-pass metabolism drastically reduces oral bioavailability — morphine F ≈ 25%; ibuprofen F ≈ 90%; aspirin F ≈ 68% after intestinal hydrolysis.
Inputs
Auc Oral Ng Ml Hr
Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
Auc Iv Ng Ml Hr
Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
Dose Oral Mg
Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
Dose Iv Mg
Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
Results
oral bioavailability F (%)
Reference formula or conversion factor shown for context.
dose-normalised AUC ratio
The proportional relationship between two quantities.
equivalent IV dose for same exposure
Sample size or count used in the calculation.
F = (AUC_po/D_po)/(AUC_IV/D_IV)
Reference formula or conversion factor shown for context.
bioavailability classification
Category assigned based on where the computed value falls on a defined scale. Check which standard or guideline defines these boundaries.