// multi-utility computation suite · offline · instant · precise
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sci.one-compartment-PK-model Calculator
Calculates plasma drug concentration from a one-compartment pharmacokinetic model: C(t) = (FD/Vd) × exp(−Ket) for IV bolus, or the oral absorption model. One-compartment model assumes instantaneous distribution — drugs with slow tissue distribution (many antibiotics, some biologics) require two-compartment models.
Inputs
Dose Mg
Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
Vd L
Three-dimensional space occupied (m³ or L). 1 m³ = 1,000 L.
Ke Hr
Amount per unit of time or per unit quantity. Check the denominator before interpreting.
T Hr
Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
Results
initial concentration C0 (mg/L)
The proportional relationship between two quantities.
concentration at time t (mg/L)
The proportional relationship between two quantities.
elimination half-life t½ (hr)
Time for half the radioactive material to decay. After 10 half-lives, less than 0.1% of the original material remains.
clearance CL (L/hr)
Sample size or count used in the calculation.
AUC (mg·hr/L)
Reference formula or conversion factor shown for context.