// multi-utility computation suite · offline · instant · precise
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sci.pharmacokinetics-two-compartment Calculator
Calculates plasma and tissue drug concentration from a two-compartment PK model with central (V₁) and peripheral (V₂) compartments, characterised by α and β half-lives. The α phase (distribution half-life) is faster than β (elimination half-life) — thiopental shows marked two-compartment behaviour: rapid induction then redistribution.
Inputs
Dose Mg
Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
A Mg L
Reference formula or conversion factor shown for context.
Alpha Per Hr
Amount per unit of time or per unit quantity. Check the denominator before interpreting.
B Mg L
Reference formula or conversion factor shown for context.
Beta Per Hr
Amount per unit of time or per unit quantity. Check the denominator before interpreting.
T Hr
Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
Results
plasma concentration C(t) (mg/L)
The proportional relationship between two quantities.
AUC₀→∞ (mg·hr/L)
Reference formula or conversion factor shown for context.
clearance CL (L/hr)
Sample size or count used in the calculation.
volume of distribution at SS Vss (L)
The computed three-dimensional volume.
C(t) = A·e^(−αt) + B·e^(−βt)
Reference formula or conversion factor shown for context.
half-lives
Reference formula or conversion factor shown for context.