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sci.sample-size-clinical-trial Calculator
Calculates required sample size per group for a clinical trial from desired power, significance level α, and minimum detectable effect size. For two-proportion test with 80% power and α = 0.05, detecting a 10% vs 15% event rate requires n = 430 per arm.
Inputs
Alpha Pct
Reference formula or conversion factor shown for context.
Power Pct
Rate of energy transfer (W). P = V×I (electrical). P = F×v (mechanical). 1 horsepower ≈ 746 W.
P1 Pct
Amount per unit of time or per unit quantity. Check the denominator before interpreting.
P2 Pct
Amount per unit of time or per unit quantity. Check the denominator before interpreting.
Results
n per group
Sample size or count used in the calculation.
total sample size
The combined total across all inputs and components.
effect size |p₁−p₂|
Standardised measure of the magnitude of the difference or relationship, independent of sample size. Cohen's d: 0.2 = small, 0.5 = medium, 0.8 = large.
n = (z_α+z_β)²·(p₁q₁+p₂q₂)/(p₁−p₂)²
Sample size or count used in the calculation.
z_α (two-tailed α=5%)
Reference formula or conversion factor shown for context.