sci.two-compartment-PK-IV Calculator
Calculates plasma and tissue drug concentrations from a two-compartment IV bolus model: C_plasma = A×e^(−αt) + B×e^(−βt) with biexponential decay. Alpha phase (distribution t½ ≈ 0.5–2 hr) reflects drug redistribution to tissues; beta phase (terminal t½) reflects elimination — gentamicin shows classic two-compartment kinetics.
Inputs
- Dose Mg
- Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
- A Mgl
- Reference formula or conversion factor shown for context.
- B Mgl
- Reference formula or conversion factor shown for context.
- Alpha Hr
- Amount per unit of time or per unit quantity. Check the denominator before interpreting.
- Beta Hr
- Amount per unit of time or per unit quantity. Check the denominator before interpreting.
- T Hr
- Amount of medication administered per period. Most dosing is weight-based — verify with a licensed prescriber before clinical use.
Results
- plasma concentration C(t) (mg/L)
- The proportional relationship between two quantities.
- AUC (mg·hr/L)
- Reference formula or conversion factor shown for context.
- terminal half-life t½β (hr)
- Time for half the radioactive material to decay. After 10 half-lives, less than 0.1% of the original material remains.
- clearance CL (L/hr)
- Sample size or count used in the calculation.
- volume of distribution at steady state Vss (L)
- The computed three-dimensional volume.
- C(t) = A·e^(−αt) + B·e^(−βt)
- Reference formula or conversion factor shown for context.
macro bolus dose compartment plasma